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KMID : 0613820100200030462
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Journal of Life Science
2010 Volume.20 No. 3 p.462 ~ p.465
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Genetic Polymorphisms and Haplotype Analysis of Sweet Taste Receptor TAS1R2 Gene in the Korean Population
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Lee Hye-Jin
Bae Jae-Woong
Kwon Tae-Jun
Sagong Bo-Rum
Kim Un-Kyung
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Abstract
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Sweetness plays an important role in providing calories and promoting appetite for food. Since it has been known that genetic factor (s) is involved in individual differences in taste sensitivity in humans, this study aimed to examine genetic variations of the TAS1R2 gene, one of the components for tasting sweet compounds, by using DNA sequencing analysis from 98 unrelated Korean subjects. As a result, 12 different single nucleotide polymorphisms (SNPs) were identified in the hTAS1R2 gene and most of them were nonsynonymous. Also, two novel SNPs were found for the first time in this study. It was noted that the frequencies of these SNPs were common in the Korean population. 20 different haplotypes with coding SNPs (cSNPs) were also found in this study. Three out of these haplotypes were common, showing frequencies of > 10%. The repertoire and frequencies of cSNPs and haplotypes in the hTAS1R2 gene will provide information that will help identify a functional ligand receptor common in the Korean population.
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KEYWORD
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Taste perception, sweet, TAS1R2 gene, single nucleotide polymorphism, haplotype
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